Since its inception, the Southwest Center has sponsored dozens of research projects that have enhanced our understanding of trans-border culture and history.
- Linguistic and literary studies of the Yaqui People of Sonora;
- Diachronic analyses of the economics, cultures, and history of northern Mexico;
- Research in comparative urban development;
- Ethnobotanical studies among the Mayo and Guarijío peoples of southern Sonora.
- Multidisciplinary studies of the region that explore cultural dimensions of plant cultivation and land use;
- Southwestern folklore;
- Study and inventory of Sonoran religious art;
- Studies in the architecture and urbanism of northwest Mexico and the American Southwest;
- Water and Food Security in the Southwest Borderlands;
- Ranching history and sustainability.